The CAS reveals new mechanism of
plant hormone signaling pathway by successfully analyzed the chelation
structure of strigolactone metabolite and DWARF14 active site, the crystal
structure of complex of receptor DWARF14 and hormone GR24, and discovered the
destabilization of DWARF144 and homologous protein DAD2 in the existence of
hormone.
Source: Bing
A research team led by Xu Huaqiang from the
Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS) jointly
with a research team led by Li Jiayang from the Institute of Genetics and
Developmental Biology, CAS, etc., successfully analyzed the chelation structure
of strigolactone metabolite and DWARF14 active site, the crystal structure of
complex of receptor DWARF14 and hormone GR24, and discovered the
destabilization of DWARF144 and homologous protein DAD2 in the existence of
hormone, revealing a new mechanism of strigolactone signaling pathway.
The related achievement was published
online in Cell Research titled Destabilization of strigolactone receptor
DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3.
Strigolactone, an important plant hormone
discovered in recent years, has important effects of awareness and signal
transduction during the process of plant growth and development and
environmental adaptation. There is still something ambiguous like the
structure, function and the mechanism of signaling pathway of strigolactone
receptor. So researches of genetics, biochemistry and structural biology of
strigolactone will provide structural basis for developing new herbicides.
The newest achievement is a significant
breakthrough in the research field of strigolactone molecular mechanism
contributed by research teams led by Xu Huaqiang and Li Jiayang. They have
published three academic papers about this field in 5 years. The first paper
was published in Cell Research and the relevant achievement analyzed the 3D
structure of strigolactone receptor protein D14 and homologous protein KA12 which
provided structural basis for further elucidation of strigolactone molecular
mechanism. And the second paper was published in Nature which elucidated that
strigolactone can regulate rice tiller and plant type by inducing the
degradation of its inhibitor D53.
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